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Image Search Results
Journal: Research
Article Title: Distinct Olfactory Bulb-Cortex Neural Circuits Coordinate Cognitive Function in Parkinson’s Disease
doi: 10.34133/research.0484
Figure Lengend Snippet: Aberrant functional connectivity (FC) across the olfactory regions in PD patients and mice. (A) Representative fMRI of the FC from olfactory bulb (OB) between PD patients and healthy control groups. (B) Heatmap of correlation of FC from OB with PC and EC. (C) Quantification of correlation of FC across olfactory circuits between PD patients ( n = 12) and healthy control groups ( n = 11). (D) Diagram of the olfactory-related working memory test. Before the test, mice are habituated to the experimental condition. In the training session, one cheese is hidden behind pole A, and the other with a metal mesh cover is placed on the top of pole B. In the test session, the cheese is removed from pole A and pole B. (E) Quantification of latency to zone A and B and total time in zone A and B during the training session between control and PD mice ( n = 5 in each group). (F) Quantification of latency to zone A and total time in zone A and B during the test session between control and PD mice ( n = 5 in each group). (G and H) OB-aPC coherence of LFPs in control and PD mice during the training session ( n = 5 in each group). (I and J) Pearson’s correlation analysis of latency to zone A and total time in zone A during the test session versus the OB-aPC coherence at the beta band in the training session ( n = 5 in each group). (K and L) OB-EC coherence of LFPs in control and PD mice during the test session ( n = 5 in each group). (M and N) Pearson’s correlation analysis of latency to zone A and total time in zone A during the test session versus the OB-EC coherence at the gamma band in the test session ( n = 5 in each group). Data are presented as mean ± SEM; ** P < 0.01, *** P < 0.001; ns, not significant. Two-way ANOVA for (C), (E), (H), and (I). Unpaired 2-tailed Student’s t test for (F).
Article Snippet: Then, the functional data were preprocessed with
Techniques: Functional Assay, Control